📍Pathological increase in the volume of the endometrium, manifested by both clinical changes and changes at the cell level. Is an underlying disease for the development of endometrial cancer. More: https://pillintrip.com/ru/medicine/citoles.
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📍But at the same time, the risk of transition of endometrial hyperplasia without atypia to endometrial cancer is less than 5% within 20 years,
❗ In most cases, hyperplasia without atypia spontaneously regresses during follow-up. ⠀
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📍Main complaints:
Abnormal uterine bleeding: very heavy and prolonged periods,
👉 intermenstrual discharge,
Shortening the cycle less than 21 days,
Any❗ menopausal bleeding
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❓Why does hyperplasia develop? ⠀
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– The main reason is an excess of estrogen, and a lack of progesterone. Under the influence of estrogens, cells grow, they are not rejected, in some cases, they can even change ⠀
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📍Risk factors: ⠀
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❗ Perimenopause (mostly) – the period when ovulation becomes irregular, progesterone levels are low ⠀
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❗Using drugs that act like estrogens ⠀
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❗ Irregular menstruation, especially associated with polycystic ovary syndrome or infertility. ⠀
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❗ Obesity, with an increase in body weight, the conversion of androgens in adipose tissue into estrogens increases; ⠀
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❗Previous medical conditions such as diabetes mellitus, gallbladder disease, or thyroid disease. ⠀
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❗Smoking, smoking disrupts estrogen metabolism and increases the amount of dangerous metabolites ⠀
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❗estrogen-secreting ovarian tumors such as granulosa cell tumors ⠀
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❗Family history of ovarian, colon, or uterine cancer (Lynch syndrome) ⠀
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📍What is hyperplasia ⠀
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According to the WHO classification in 2014, it allocates ⠀
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hyperplasia without atypia ⠀
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atypical hyperplasia. ⠀

Diagnostics: ⠀
Ultrasound with measurement of endometrial thickness ⠀
In postmenopausal women, a threshold has been proposed for excluding endometrial cancer, and it has been shown that the likelihood of cancer is reduced to less than 1% when the thickness of the endometrium is less than 3-4 mm.